Abstract Background: the vascular endothelial growth factor (VEGF) pathway plays a prominent role in the growth and progression of human cancer, including non-small cell lung carcinoma (NSCLC). The key mediators...
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Abstract Background: the vascular endothelial growth factor (VEGF) pathway plays a prominent role in the growth and progression of…
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Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue
Abstract Historical data have indicated the potential for the histologically-normal breast to harbor pre-malignant changes at the molecular level. We postulated that a histologically-normal tissue with ‘‘tumor-like’’ gene expression pattern...
READ MOREEvaluation of malignancy-risk gene signature in breast cancer patients
Abstract We recently developed a malignancy-risk gene signature that was shown to identify histologically-normal tissues with a cancer-like profile. Because the signature was rich with proliferative genes, we postulated it...
READ MOREMeasuring Cross-Cultural Perception of Educational Environment among Postgraduates by Using Postgraduate Hospital Educational Environment Measure (PHEEM) Inventory
Abstract Background: A postgraduate training program should be focused on positive and healthy educational environment. Postgraduate trainees suffer invariably during their training when the hospital educational environment is stressful. It...
READ MOREStromal-Based Signatures for the Classification of Gastric Cancer
Abstract Treatment of metastatic gastric cancer typically involves chemotherapy and monoclonal antibodies targeting HER2 (ERBB2) and VEGFR2 (KDR). However, reliable methods to identify patients who would benefit most from a...
READ MOREHeterogeneity of Vascular Endothelial Growth Factor Receptors1, 2, 3 in Primary Human Colorectal Carcinoma
Abstract. Background: The vascular endothelial growth factor (VEGF) pathway plays an important role in growth and progression of human cancer, including colorectal carcinomas (CRC). The key mediators of VEGF signaling...
READ MORESomatostatin Receptor Profiling in Hepatic Metastases From Small Intestinal and Pancreatic Neuroendocrine Neoplasms: Immunohistochemical Approach With Potential Clinical Utility
Background: The expression of somatostatin receptors (SSTRs) on endocrine tumor (ET) cells forms the basis for somatostatin analog treatment of patients with SSTR-positive, hormonally active ETs. In patients with SSTRnegative...
READ MOREDifferential expression of VEGFR2protein in HER2 positive primary human breastcancer: potential relevance to anti‑angiogenictherapies
Abstract Background: Clinically relevant predictive biomarkers to tailor anti-angiogenic therapies to breast cancer (BRC) patient subpopulations are an unmet need.Methods: We analyzed tumor vascular density and VEGFR2 protein expression in...
READ MOREEfficacy and safety of ramucirumabcontaining chemotherapy in patients with pretreated metastatic gastric neuroendocrine carcinoma
Abstract Background Ramucirumab (RAM), a monoclonal antibody for vascular endothelial growth factor 2 (VEGFR2), has been effective for advanced gastric adenocarcinoma (AC). However, little is known about the efficacy of...
READ MOREHybrid Model Integrating Immunohistochemistry andExpression Profiling for the Classification ofCarcinomas of Unknown Primary Site
Identification of the site of origin for ‘malignancy with unknown primary’ remains a challenge for modern pathology. Correct diagnosis is critical to defining the most beneficial treatment for the patient....
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Abstract Background: the vascular endothelial growth factor (VEGF) pathway plays a prominent role in the growth and progression of human cancer, including non-small cell lung carcinoma (NSCLC). The key mediators of VEGF signaling are a family of related receptor tyrosine kinases that include VEGFR1, VEGFR2, and VEGFR3. The relative expression…
Abstract Historical data have indicated the potential for the histologically-normal breast to harbor pre-malignant changes at the molecular level. We postulated that a histologically-normal tissue with ‘‘tumor-like’’ gene expression pattern might harbor substantial risk for future cancer development. Genes associated with these high-risk tissues were considered to be ‘‘malignancy-risk genes’’.…
Abstract We recently developed a malignancy-risk gene signature that was shown to identify histologically-normal tissues with a cancer-like profile. Because the signature was rich with proliferative genes, we postulated it might also be prognostic for existing breast cancers. We evaluated the malignancy risk gene signature to see its clinical association…
Abstract Background: A postgraduate training program should be focused on positive and healthy educational environment. Postgraduate trainees suffer invariably during their training when the hospital educational environment is stressful. It is, therefore very important to assess the training environment of an institute as a part of good educational practice.Aims: The…
Abstract Treatment of metastatic gastric cancer typically involves chemotherapy and monoclonal antibodies targeting HER2 (ERBB2) and VEGFR2 (KDR). However, reliable methods to identify patients who would benefit most from a combination of treatment modalities targeting the tumor stroma, including newimmunotherapy approaches, are still lacking. Therefore, we integrated a mouse model…
Abstract. Background: The vascular endothelial growth factor (VEGF) pathway plays an important role in growth and progression of human cancer, including colorectal carcinomas (CRC). The key mediators of VEGF signaling are VEGFR1, VEGFR2, and VEGFR3, part of a family of related receptor tyrosine kinases. The relative expression, activity, or interplay…
Background: The expression of somatostatin receptors (SSTRs) on endocrine tumor (ET) cells forms the basis for somatostatin analog treatment of patients with SSTR-positive, hormonally active ETs. In patients with SSTRnegative ETs, the clinical response is generally absent or suboptimal, while nonfunctioning ETs with SSTR positivity show a variable response to…
Abstract Background: Clinically relevant predictive biomarkers to tailor anti-angiogenic therapies to breast cancer (BRC) patient subpopulations are an unmet need.Methods: We analyzed tumor vascular density and VEGFR2 protein expression in various subsets of primary human BRCs (186 females; Mean age: 59 years; range 33–88 years), using a tissue microarray. Discrete…
Abstract Background Ramucirumab (RAM), a monoclonal antibody for vascular endothelial growth factor 2 (VEGFR2), has been effective for advanced gastric adenocarcinoma (AC). However, little is known about the efficacy of RAM-containing chemotherapy (RAM-CTx) in gastric neuroendocrine carcinoma (G-NEC).Methods We retrospectively analysed and compared the clinical outcomes of patients (pts) with…
Identification of the site of origin for ‘malignancy with unknown primary’ remains a challenge for modern pathology. Correct diagnosis is critical to defining the most beneficial treatment for the patient. Standard pathological approaches combine morphology and immunohistochemical (IHC) studies to first subclassify cytokeratin-positive carcinomas into adenocarcinoma, squamous cell carcinoma, neuroendocrine…