Profiling of Vascular Endothelial Growth Factor Receptor Heterogeneity Identifies Protein Expression-defined Subclasses of Human Non-small Cell Lung Carcinoma

Abstract Background: the vascular endothelial growth factor (VEGF) pathway plays a prominent role in the growth and progression of human cancer, including non-small cell lung carcinoma (NSCLC). The key mediators…

Continue ReadingProfiling of Vascular Endothelial Growth Factor Receptor Heterogeneity Identifies Protein Expression-defined Subclasses of Human Non-small Cell Lung Carcinoma

Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue

Abstract Historical data have indicated the potential for the histologically-normal breast to harbor pre-malignant changes at the molecular level. We postulated that a histologically-normal tissue with ‘‘tumor-like’’ gene expression pattern…

Continue ReadingProliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue

Measuring Cross-Cultural Perception of Educational Environment among Postgraduates by Using Postgraduate Hospital Educational Environment Measure (PHEEM) Inventory

Abstract Background: A postgraduate training program should be focused on positive and healthy educational environment. Postgraduate trainees suffer invariably during their training when the hospital educational environment is stressful. It…

Continue ReadingMeasuring Cross-Cultural Perception of Educational Environment among Postgraduates by Using Postgraduate Hospital Educational Environment Measure (PHEEM) Inventory

Heterogeneity of Vascular Endothelial Growth Factor Receptors1, 2, 3 in Primary Human Colorectal Carcinoma

Abstract. Background: The vascular endothelial growth factor (VEGF) pathway plays an important role in growth and progression of human cancer, including colorectal carcinomas (CRC). The key mediators of VEGF signaling…

Continue ReadingHeterogeneity of Vascular Endothelial Growth Factor Receptors1, 2, 3 in Primary Human Colorectal Carcinoma

Somatostatin Receptor Profiling in Hepatic Metastases From Small Intestinal and Pancreatic Neuroendocrine Neoplasms: Immunohistochemical Approach With Potential Clinical Utility

Background: The expression of somatostatin receptors (SSTRs) on endocrine tumor (ET) cells forms the basis for somatostatin analog treatment of patients with SSTR-positive, hormonally active ETs. In patients with SSTRnegative…

Continue ReadingSomatostatin Receptor Profiling in Hepatic Metastases From Small Intestinal and Pancreatic Neuroendocrine Neoplasms: Immunohistochemical Approach With Potential Clinical Utility

Differential expression of VEGFR2protein in HER2 positive primary human breastcancer: potential relevance to anti‑angiogenictherapies

Abstract Background: Clinically relevant predictive biomarkers to tailor anti-angiogenic therapies to breast cancer (BRC) patient subpopulations are an unmet need.Methods: We analyzed tumor vascular density and VEGFR2 protein expression in…

Continue ReadingDifferential expression of VEGFR2protein in HER2 positive primary human breastcancer: potential relevance to anti‑angiogenictherapies