Journal Articles

Abstract Background Ramucirumab (RAM), a monoclonal antibody for vascular endothelial growth factor 2 (VEGFR2), has been effective for advanced gastric adenocarcinoma (AC). However, little is known about the efficacy of RAM-containing chemotherapy (RAM-CTx) in gastric neuroendocrine carcinoma (G-NEC).Methods We retrospectively analysed and compared the clinical outcomes of patients (pts) with G-NEC receiving RAM-CTx, G-NEC receiving CTx without RAM and AC receiving RAM-CTx in our hospital. G-NEC was defined…

Identification of the site of origin for ‘malignancy with unknown primary’ remains a challenge for modern pathology. Correct diagnosis is critical to defining the most beneficial treatment for the patient. Standard pathological approaches combine morphology and immunohistochemical (IHC) studies to first subclassify cytokeratin-positive carcinomas into adenocarcinoma, squamous cell carcinoma, neuroendocrine carcinoma, and urothelial carcinoma. Subsequently, organ-specific IHC-markers, if available, are used to assign the tumor’s primary site of…

Abstract Objective: To assess clinicopathological characteristics of primary gastro-entero-pancreatic poorlydifferentiated neuroendocrine carcinomas (GEP-PDNECAs) and evaluate overall survival in patients treatedwith systemic platinum and etoposide therapy.Methods: A detailed retrospective review of clinico-pathologic data (1999-2009) on 68 consecutive adultpatients with primary GEP-PDNECAs was carried out, from H Lee Moffit Cancer Center and Research Institute, Tampa, Florida; USA, based on electronic patient records, specialty consultation files, tumor registry, social security index…

Editors: Aejaz Nasir, Domenico CoppolaPublisher: Springer-Verlag, New YorkLanguage: EnglishYear: 2016eBook ISBN: 978-1-4939-3426-3Hardcover ISBN: 978-1-4939-3424-9No. of pages: XIII, 543 The first edition of “Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances” starts from a pathology perspective in a very dynamic field which requires a multidisciplinary approach. A collaborative effort including endocrinologists, radiologists, surgeons, pathologists, oncologists explains the huge progress done in this complex puzzle of neuroendocrine tumors. The…

Abstract A robust immunohistochemical (IHC) assay for VEGFR2 was developed to investigate its utility for patient tailoring in clinical trials. The sensitivity, specificity, and selectivity of the IHC assay were established by siRNA knockdown, immunoblotting, mass spectrometry, and pre-absorption experiments. Characterization of the assay included screening a panel of multiple human cancer tissues and an independent cohort of non-small cell lung carcinoma (NSCLC, n = 118) characterized by…

Abstract Background: Understanding the concept of resuscitation is extremely important in the professional life of all healthcare workers. By achieving the appropriate resuscitation knowledge and psychomotor skills, the efficacy of performance can be enhanced in real‑time situations. The level of resuscitation knowledge differs among healthcare workers, and inadequate knowledge raises a considerable concern about the effectiveness when it is performed in real life. Aims: The aim of the…